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Fig. 2A —Perfusion CT image of rectal carcinoma performed to assess response to chemotherapy and radiation therapy. (Reprinted with permission from Sahani DV, Kalva SP, Hamberg LM, et al. Assessing tumor perfusion and treatment response in rectal cancer with multisection CT: initial observations. Radiology 2005; 234:785-792 [36].) Color-coded blood flow map in which areas of highest blood flow are shown in red, followed by yellow, indicates regions of highest blood flow are scattered throughout much of central portion of mass.