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Fig. 2B —Perfusion CT image of rectal carcinoma performed to assess response to chemotherapy and radiation therapy. (Reprinted with permission from Sahani DV, Kalva SP, Hamberg LM, et al. Assessing tumor perfusion and treatment response in rectal cancer with multisection CT: initial observations. Radiology 2005; 234:785-792 [36].) Color-coded permeability-surface area product map—in which areas of highest permeability-surface area product are shown in red and yellow—indicates that regions of highest permeability are scattered throughout much of tumor.