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Fig. 2C —59-year-old man with nephrogenic systemic fibrosis (NSF) with both skeletal muscle and skin findings. Axial T1- and fat-suppressed T2-weighted images of thighs show symmetric skin thickening and edema in medial thighs. There is also marked edema in subcutaneous fat, intermuscular fascia, and thigh muscles with some sparing of posterior thigh muscles.