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Fig. 2D —19-year-old man with glioblastoma multiforme. Two types of infusion failure were seen in this patient. Forty-eight hours after initiation of convection-enhanced infusion, leakage of infusate into subarachnoid CSF space occurred, and hyperintense signal did not develop on T2-weighted MR images. A-C, Images show failure due to catheter crossing sulcus within backflow region. D-F, Images show failure due to placement of catheter tip within subarachnoid space. Human figure indicates imaging plane. Blue line and indicates plane perpendicular to catheter shown in C and F. Thick red and thicker and lighter blue indicate catheter trajectories. Axial T2-weighted image depicting trajectory of second catheter (turquoise line) shows end of catheter projecting into subarachnoid space and wholly extraparenchymal infusate volume (outline). Hyperintense signal is not present around catheter tip.