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Fig. 1B —19-year-old man (A-E) and 56-year-old man (F-J) with glioblastoma multiforme. Serial increases in MR signal intensity after successful convection-enhanced infusion in two patients with little or no preexisting signal abnormality directly at catheter tip. In both patients morphology of region of hyperintense signal abnormality on MRI closely matches distribution of infusate seen on SPECT. Human figure indicates imaging plane. Blue line indicates plane perpendicular to tip of catheter. Green line indicates catheter trajectory. Axial T2-weighted image 24 hours after beginning of infusion shows development of new hyperintense signal abnormality at catheter tip.