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Fig. 1B Schematics illustrate three stages of spinal cord development.
Canalization occurs when multiple microcysts form and coalesce in caudal cell
mass (arrows), which fuses to distal neural tube
(arrowheads), forming primitive spinal cord. (Reprinted with
permission from Barkovich AJ. Normal development of the neonatal and infant
brain, skull and spine. In: Barkovich AJ. Pediatric neuroimaging, 3rd
ed. Philadelphia, PA: Lippincott Williams & Wilkins, 2000:624
[2])