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Fig. 3E —44-year-old man with no history of leukemia who presented with jaundice and fever with total bilirubin of 9.5 mg/dL. Photograph of gross pathologic specimen shows ill-defined, diffusely fibrotic, and thickened extrahepatic bile duct (arrows). Intrahepatic bile duct wall is mildly thickened due to inflammatory and fibrotic change.