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Fig. 2 —Measuring water diffusion. Stejskal and Tanner [10] adopted T2-weighted spin-echo sequence for measuring water diffusion. They applied symmetric diffusion-sensitizing gradient around 180° refocusing pulse. On this schematic drawing, stationary molecules are unaffected by gradients and measured signal intensity is preserved. By contrast, moving water molecules acquire phase information from first gradient, which is not entirely rephased by second gradient, thereby leading to signal loss. Hence, water diffusion is detected as attenuation of measured MR signal intensity. RF = radiofrequency pulse.