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Fig. 1A —58-year-old man with metastatic renal cell carcinoma. Axial contrast-enhanced CT images obtained with CT perfusion software before treatment (A) and after 12 weeks (B) and 24 weeks (C) of thalidomide treatment. Regions of interest were placed within aorta to define arterial input and drawn freehand around metastatic lesion of renal cell carcinoma (arrow) in liver.