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Fig. 3C —Missed cancers at index endoscopy. Coronal 2D multiplanar reformation image in 65-year-old man shows large lobulated polyp (arrow) at rectosigmoid junction. Lesion was identified at three of four interpretations and missed by one reviewer using primary 2D search and 2.5-mm slice thickness. Surgical specimen revealed 3.2-cm invasive adenocarcinoma extending into pericolic fat.