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Figure 1


Fig. 1A —77-year-old man with solid nodule with irregular margins containing air bronchograms with doubling time consistent with malignant lesion (cancer # 1). For CT examinations, t, t–1, and t–2, respectively, designate current, most recent prior examination, and second most recent prior examination. Numbers marked with C are automatically generated by computer-aided detection (CAD) system and indicate presence of nodule candidate. On baseline CT image acquired at time t–2 (not part of observer study), radiologist who generated official clinical report missed 4.3-mm nonspecific ground-glass opacity (green circle). CAD detected and marked this lesion on this and subsequent examinations (green circles, B and C).