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Figure 3


Fig. 1C —77-year-old man with solid nodule with irregular margins containing air bronchograms with doubling time consistent with malignant lesion (cancer # 1). For CT examinations, t, t–1, and t–2, respectively, designate current, most recent prior examination, and second most recent prior examination. Numbers marked with C are automatically generated by computer-aided detection (CAD) system and indicate presence of nodule candidate. On image from second follow-up CT at time t (84 days), 3 months later, after antibiotic therapy, nodule appears slightly larger. Between B and C, CAD calculated volumetric growth, and doubling time was 23.8% and 269 days, again compatible with malignant lesion (biopsy-proven adenocarcinoma).