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Fig. 2D —53-year-old man with numerous metastatic nodules from renal cell carcinoma and unmatched nodule in lingula. Transverse (C) and coronal reformatted (D) CT images show follow-up findings. Overall matching rate was 30% (3/10). Matched volume of interest (VOI) in C and D is present in wrong place over lung parenchyma without including nodule. Correct nodule (not shown) that should be matched was located two sections superior to VOI. Matching rate is low, likely because of substantial difference in inspiration levels between CT studies. (Inspiration level difference is not evident in figures, which are screen capture images centered at matching VOIs.)