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Fig. 6A —64-year-old man with pulmonary embolism. Axial CT images at simulated one-half dose (90 mAs_eff) (A) and lowest dose (10 mAs_eff) (B) illustrate how technical factor limits detection of pulmonary embolism on low-dose images. Diagnosis of pulmonary embolism, including right lower lobe embolus (arrowhead, A) was missed by two of four readers at lowest dose. All four readers rated study as technically inadequate owing to improper timing of bolus administration of IV of contrast material.