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Fig. 2F —41-year-old woman with intermediate-grade primary angiosarcoma who presented with fullness and engorgement of right breast. (Parts B and D reprinted from Glazebrook KN, Morton MJ, Reynolds C. Vascular tumors of the breast: mammographic, sonographic, and MRI appearances. AJR 2005; 184:331–338 [7]) Photomicrograph of histopathologic specimen shows intermediate-grade angiosarcoma with distinct open, anastomosing vascular channels that surround and invade lobules. Vascular channels show infiltration into fat. Malignant endothelial cells lining vascular channels are flat, and most nuclei are pale and small. (H and E, x10)