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Fig. 3A —79-year-old woman with high-grade secondary angiosarcoma who presented with extensive discoloration of right breast. She had undergone breast conservation radiation therapy for 1.5-cm grade 2 node-negative, estrogen receptor–and progesterone receptor–positive invasive ductal carcinoma 5 years earlier. Sonogram of palpable, soft-tissue nodule shows only diffuse skin thickening (arrow) but no discrete mass.