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Fig. 1A —Principles of real-time temporal maximum-intensity-projection imaging technique. Open-shutter photograph of fireworks in night sky is comparable with temporal maximum-intensity-projection image. Shutter of camera is held open for sufficient time to trace path of bright, moving object, such as sparks of fireworks. Method can be applied to echoes of individual bubbles of contrast agent detected with nonlinear sonography. (Courtesy of Ben Burns)