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Fig. 5B —Dual-energy subtraction radiographs in 66-year-old woman (number 10 in Fig. 3) with missed squamous cell carcinoma in left upper lobe. Soft-tissue image (B) clearly shows missed cancer (arrow, B) and bone image (C) shows that other lesion is a fracture callus (arrow, C). Note that two radiologists detected cancer without dual-energy subtraction image, whereas five radiologists (three more) detected it with dual-energy subtraction image in this observer study.