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Fig. 3 —Graph shows correspondence between hippocampal signal intensity on initial imaging and changes in hippocampal volumes over time with superimposed linear fit of data (black line). Strong correlation is shown between degree of hippocampal signal abnormality and degree of volume loss (R = 0.756). Hippocampal signal intensity was graded on a numeric scale as follows: 0 = normal, 1 = minimally increased, 2 = mildly increased, 3 = moderately increased, or 4 = markedly increased.