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Fig. 4B —Bilateral hippocampal volume loss despite initial signal abnormality in only one hippocampus in 28-month-old female infant (patient 1) with febrile status epilepticus. Seizure activity was localized to right cerebral hemisphere and was manifested by left arm and leg twitching lasting 216 minutes. Coronal T2-weighted fast spin-echo MR image obtained 9 months after status epilepticus shows right hippocampus still has increased signal intensity, although it has diminished from initial scan shown in A. On this study, right hippocampal signal intensity was graded as mildly increased (score of 2) and left hippocampal was again graded as normal (score of 0). Compared with initial image shown in A, on visual inspection alone moderate decrease in size of right hippocampus and mild decrease in size of left hippocampus are seen. On volumetric analysis, right hippocampal volume was found to be decreased by 1,084 mm³ and left hippocampal volume decreased by 232 mm³.