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Fig. 3 —Photomicrograph shows histology of nonalcoholic steatohepatitis in 62-year-old woman. Mallory's hyaline bodies (pink filamentous structures, black arrowhead) are cytoplasmic inclusions in hepatocytes consisting of abnormal keratin, hyaline, and other proteins. They are usually found in hepatocytes that are ballooned (black arrow) and are morphologic hallmarks of alcoholic and nonalcoholic steatohepatitis. Mallory's bodies are not cause but rather consequence of cellular injury. Usually hepatocytes with Mallory's bodies do not contain large fat vacuoles, although microvesicular fat may be seen. In this frame, other hepatocytes are present, containing macrovesicular fat globules (white arrow), which occupy almost all cytoplasm, displacing nucleus (white arrowhead) to periphery. (H and E, x 400) (Courtesy of Romil Saxena, Department of Pathology, Indiana Universtiy School of Medicine)