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Fig. 1A —4-year-old girl with tuberous sclerosis complex. Axial T1-weighted (A) and T2-weighted (B) MR images show T1 hypointensity (arrows, A) and T2 hyperintensity (arrows, B) in subcortical white matter of left frontal and right parietal lobes. Gray–white matter differentiation is partially obliterated. Findings are characteristic of cortical and subcortical tubers.