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Fig. 1 —Analysis of kinetics with signal enhancement ratio. Graph shows signal intensity (S) versus time (t). S₀, S₁, and S₂ represent signal intensity of images obtained at t₀ (before contrast injection), t₁ (2.5 minutes after contrast injection), and t₂ (7.5 minutes after contrast injection), respectively. Three curves display different patterns of signal increase and washout that are seen with time: bottom curve shows slow gradual increase in enhancement, more characteristic of normal tissue; middle curve shows early enhancement with little washout, essentially a plateau in signal intensity; top curve shows pattern of early enhancement with quick washout, which is more characteristic of highly vascularized tissue and neoangiogenic vessels. Signal enhancement ratio is measured as the increase in signal intensity at t₁ relative to baseline (t₀) divided by increase from baseline to t₂: (S₁ - S₀)/(S₂ - S₀).