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Fig. 2B —Selection of regions of interest (ROIs) on dynamic contrast-enhanced MRI in 42-year-old woman with invasive ductal carcinoma. First contrast-enhanced MR image (at t₁ [2.5 minutes after contrast injection]) shows two sets of five ROIs, each 5 mm in diameter, extend radially from tumor edge. The first ROI in one set was placed in visible tumor (T) and next four ROIs were placed in normal-appearing breast fibroglandular stroma (S). The second set of similarly placed ROIs was obtained along a different radius for each scan if enough normal (nonenhancing) stroma was present.