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Fig. 2C —Scatterplots of ¹⁸F-FDG uptake in lesions. Scatterplots show average and maximum standard uptake values (SUV_avg and SUV_max) (A), average tumor-to-cortex activity ratio (T/C_avg) and ratio of count of maximum pixels in tumor to average count per pixel in cortex (T/C_max) (B), and average tumor-to-white matter activity ratio (T/WM_avg) and ratio of count of maximum pixels in tumor to average count per pixel in white matter (T/WM_max) (C). L denotes CNS lymphoma; G, high-grade glioma; and M, metastatic brain tumor. Mean values and SDs are also shown. Dashed lines indicate lowest values for each CNS lymphoma parameter. When these values are used as cutoff levels to distinguish CNS lymphomas from other tumors, SUV_max is the most accurate parameter. Using SUV_max of 15.0 as cutoff level, only one high-grade glioma was found to be false-positive (SUV_max, 18.8) in our patient group.