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Fig. 2C —Perfusion CT maps of two rats from sorafenib-treated group show decrease in tumor volume and blood flow from days 0–9. Maps of rat 1 (A–C) and rat 2 (D–F) at days 0 (A and D), 4 (B and E), and 9 (C and F). Blood flow in each perfusion map is represented in color-coding scheme in rainbow format such that flow of 0 mL/min/100 g is shown in black and maximal blood flow (50 mL/min/100 g) is shown in bright red. Flow values between 0 and 50 mL/min/100 g are represented as varying shades of blue, green, yellow, and red in order of increasing perfusion. In addition, these figures show development of rim of increased perfusion (arrows, C and F) in sorafenib-treated tumors despite continued decrease in tumor volume. This could possibly represent early development of tumor resistance to antiangiogenic therapy.