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Fig. 4 —Joint Photographic Experts Group (JPEG) compression artifacts in transverse low-dose chest CT image in 72-year-old man with solid nodule. Although lungs and chest wall and mediastinum were segmented in our experiment, unsegmented original image (top left) and Fig. S4A, which can be viewed from the information box in the upper right corner of the article at www.ajronline.org, and 10:1 compressed image (top right and Fig. S4B) are presented here and in Figures S4A and S4B to better depict regional difference in artifacts. Blurring artifacts are more prominent in chest wall than in lung. Note that this regional difference in perceptual artifacts is better reproduced by High–Dynamic Range Visual Difference Predictor (HDR-VDP) map (bottom right) than by mathematical subtraction image (bottom left). Region of interest for original and compressed images is smaller than that of subtraction image and HDR-VDP map. Arrow points to solid nodule.