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Fig. 3 —Photograph shows late stage of nephrogenic systemic fibrosis in patient with plaques and skin induration of both legs up to thighs and flexion contractures. Skin involvement is symmetric and bilateral. Affected skin is hairless, sclerotic, and brown. (Reprinted with permission of [67]; Khurram M, Skov L, Rossen K, Thomsen HS, Marckmann P. Nephrogenic systemic fibrosis: a serious iatrogenic disease of renal failure patients. Scand J Urol Nephrol 2007; 41:565–566; courtesy of Henrik S. Thomsen, Copenhagen University Hospital, Herlev, Denmark [www.informaworld.com/suro])