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Fig. 1E —Assessment of initial and late enhancement before initiating chemotherapy in 49-year-old woman. Simultaneous viewing of subtracted images for initial enhancement (A–C) and late enhancement (D–F) in sagittal (A, D), axial (B, E), and coronal (C, F) planes. Shown are measurements of largest tumor diameter of late enhancement in three planes containing tumor with necrotic core.