WILMS' TUMOR

A SUMMARY OF 25 YEARS OF EXPERIENCE BEFORE ACTINOMYCIN-D

¹ Department of Radiology, Lakeland General Hospital, Lakeland, Florida
² Instructor and James Picker Scholar in Radiologic Research, Department of Radiology, University of Minnesota Hospitals, Minneapolis, Minnesota
³ Northwestern Hospital, Minneapolis, Minnesota

Forty-six proven cases of Wilms' tumor are reported. The series is representative of the natural history of this disease prior to the use of actinomycin-D. No uniform method of treatment was employed. Most cases were treated by a combination of surgery and irradiation. The overall survival rate was 39 per cent. None of the patients who had metastasis on admission survived. Of 25 patients who did not receive treatment elsewhere and who were free of metastasis at the time of admission, 60 per cent survive. The prognosis was more favorable in those patients who were under 2 years of age (60 per cent survival) and was excellent when the renal capsule was intact without evidence of tumor spread beyond the kidney at the time of surgery (84 per cent survival). Pulmonary metastases were successfully treated in 2 patients.

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