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American Journal of Roentgenology, Vol 102, 43-45, Copyright © 1968 by American Roentgen Ray Society

OXYGEN AND L-TRIIODOTHYRONINE IN RADIOTHERAPY OF MOUSE TUMORS

LUCILLE A. DU SAULT 1

1 Radiation Physics, Department of Radiology, Henry Ford Hospital, Detroit, Michigan

Mice receiving radiotherapy of breast tumors, after having been made hyperthyroid by T3 medication or while breathing 95% O2+5% CO2, showed an increased cure rate over mice treated while breathing air, but without increased systemic effects.

When both T3 and O2/CO2 were used, the death rate during treatment was doubled and the cure rate no further improved.

In some situations T3 medication may be superior to oxygen at high pressure as a means of improving oxygenation of tumor cells during radiotherapy, while in other situations it may be inferior.


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Copyright © 1968 by the American Roentgen Ray Society.