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American Journal of Roentgenology, Vol 104, 668-673, Copyright © 1968 by American Roentgen Ray Society

SPLEEN IRRADIATION IN SECONDARY HYPERSPLENISM

F. V. COMAS 1, G. A. ANDREWS 1, and B. NELSON 1

1 From the Medical Division, Oak Ridge Associated Universities, Oak Ridge, Tennessee, under contract with the United States Atomic Energy Commission

The purpose of this study was to determine the effect of splenic irradiation on the hematologic manifestations of hypersplenism: hemolytic anemia, granulocytopenia, and thrombocytopenia.

Eight patients with hypersplenism secondary to various diseases had their spleens irradiated with doses of between 700 and 2,000 r in a period of 8 to 17 days. Although most of the patients had some clinical improvement, related particularly to the reduction in spleen size, the hypersplenic manifestations showed little response to the treatment. Only 1 patient had a lasting remission of hemolytic anemia, and even this was not clearly attributable to splenic irradiation.

Splenectomy was effective in controlling hypersplenism, and, when feasible, is the treatment of choice for this condition.


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Copyright © 1968 by the American Roentgen Ray Society.