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PILOT STUDY OF DOSE FRACTIONATION IN CARCINOMA OF THE BASE OF THE TONGUE: UNINTERRUPTED VS. SPLIT-COURSE IRRADIATION

VICTOR A. MARCIAL M.D. and ZENAIDA FRIAS M.P.H.

A prospective study of 4 fractionation regimes for advanced carcinoma of the base of the tongue is presented. The treatment categories were: uninterrupted irradiation with daily fractions of 170 r up to 6,ooo r; uninterrupted irradiation with 3 fractions per week of 285 r up to 6,ooo r; a split-course technique with daily fractions of 300 r up to 3,000 r, followed by a rest period of approximately 3 weeks, then a repetition of the initial irradiation; and a similar split-course technique with 3 fractions per week of 500 r each.

Normal tissue reactions, completion of therapy, tumor response, and 2 year disease free survival are discussed.

The results of this study favor the split-course technique with daily fractions of 300 r; however, the limited number of cases involved does not permit a valid conclusion.

The need exists for a larger scale, properly planned study to compare the split-course technique with the usual conventional uninterrupted therapy for various cancer sites.


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