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LATE RECURRENCE OF INFANTILE CORTICAL HYPEROSTOSIS (CAFFEY'S DISEASE)

BARRY A. SWERDLOFF M.D., M. B. OZONOFF M.D., and MICHAEL T. GYEPES M.D.

Two patients, a 12 year old boy and a 5 year old girl, are reported with clinical, laboratory and roentgenographic findings which strongly suggest late recurrence of infantile cortical hyperostosis (Caffey's disease). Both of these children had well documented Caffey's disease as infants. Case I, the 12 year old boy, appears to be the oldest reported case of recurrence of this disease with roentgenographic documentation.

In children with symptomatic and unexplained subperiosteal new bone formation (PNB) where both clinical and roentgenographic changes wax and wane, the possibility of recurrent Caffey's disease should be considered. If appropriate documentation of infantile Caffey's disease can be obtained, these patients can probably be safely followed without the necessity of biopsy or other drastic diagnostic procedures.


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