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THE EFFECT OF GLUCAGON ON RENAL HEMODYNAMICS AND RENAL ARTERIOGRAPHY

RICHARD O. DANFORD M.D.1

1 USPHS Trainee, Diagnostic Radiology. Winner of the Memorial Medal Award of the Association of University Radiologists, 1969.

Renal arteriography before and after infusion of 0.5 mg. of glucagon into the renal vascular bed using both routine and magnification roentgenographic techniques reveals vasodilatation lasting up to 120 minutes throughout the entire arterial tree with improved visualization of the small vessels. Measurement of renal blood flow by a dye dilution technique shows an average rise of 65 cc. min. with no change in appearance time but a concomitant fall in mean transit time. In association with the increase in renal blood flow, there is a fall in the PAH extraction ratio. These results suggest that glucagon might be a useful pharmacologic adjunct in renal arteriography, particularly because of its prolonged effect.


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