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TAMM—HORSFALL URINARY MUCOPROTEIN PRECIPITATION BY UROGRAPHIC CONTRAST AGENTS: IN VITRO STUDIES

ROBERT H. SCHWARTZ M.D., WALTER E. BERDON M.D., JOHN WAGNER B.S., JOSHUA BECKER M.D., and DAVID H. BAKER M.D.

In vitro tests of Tamm—Horsfall urinary mucoprotein mixed with currently used urographic contrast agents are reported. A viscid gel could be induced in certain concentrations; acidification increased such protein precipitation.

These findings, in terms of the trend to higher pyelographic dosage, suggest the need for caution in the use of dehydration. The patient most at risk seems to be the azotemic patient with low urine output who undergoes infusion pyelography.


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