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1 Mallinckrodt Chemical Fellow in Nuclear Medicine.
A new technique using quantitative transmission radiography affords a clinical assessment of regional pulmonary function in man. This has been useful as an adjunct to perfusion lung scintiscanning by identifying the change in thoracic density during respiration, thus allowing us to distinguish some patients with altered regional perfusion due to inhomogeneous ventilation from those with normal ventilation and diminished perfusion due to pulmonary embolism.
The method proposed is far simpler than either radioactive gas or particle inhalation techniques. In addition, the computer processing may well permit data storage (to define the limits of normal) and computer interpretation (to discern variations from the normal).
Finally, the early recognition of alterations in ventilation in a large screened population may assist in the early diagnosis of disordered regional pulmonary function as has been seen in bronchogenic carcinoma and pulmonary emphysema.
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