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ATYPICAL CHANGES IN THYROID FOLLICULAR CELLS SECONDARY TO RADIOIODINE

EDUARDO MURPHY S. 1 and Q. F. B. CELIA CERVANTES R. 2

1 Pathologist, Division of Nuclear Medicine, National commission of Nuclear Medicine.
2 Biologist, Division of Nuclear Medicine, National Commission of Nuclear Medicine.

In the course of the last 20 years the world medical literature has reported several instances of the difficulties of interpreting microscopic alterations in thyroid tissue when the patient had been previously treated with radioactive iodine. Nonetheless, these microscopic findings have never been adequately described or produced experimentally. It is generally felt that in the human patient they are not preneoplastic; however, in the rat, many authors have reported the production of thyroid neoplasms by the use of iodine 131.

In the present paper the authors have given a clear description of the microscopic changes involved, and report on their experimental production in the rat thyroid.

They discuss the significance of these alterations in human patients and in the rat.


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