Se⁷⁵ SELENOMETHIONINE ISOTOPE LYMPHOGRAPHY IN LYMPHOMA: CORRELATION WITH LYMPHANGIOGRAPHY

¹ Assistant Radiologist at the Massachusetts General Hospital, Harvard Medical School; Instructor in Radiology, Massachusetts General Hospital.
² Clinical Fellow in Radiology at the Massachusetts General Hospital, Harvard Medical School; Resident in Radiology, Massachusetts General Hospital.
³ Formerly, Assistant Clinical Professor of Radiology, Harvard Medical School;Associate Radiologist, Massachusetts General Hospital.

Concentration of intravenously administered Se⁷⁵ selenomethionine in lymphoma tissue permits scintigraphy of these neoplasms. The diagnostic accuracy of the simple and well-tolerated isotope lymphogram was evaluated in a series of 33 lymphoma patients whose disease was staged by roentgen lymphangiography. The technique for scintigraphy was refined, and normal and abnormal patterns of selenium 75 distribution were determined using the roentgen lymphangiogram as a standard. The comparison showed that a negative isotope study did not reliably exclude disease, whereas an abnormal scintigram indicated a 70 to 80 per cent likelihood that disease was present. Certain patterns of selenium 75 distribution were reliable evidence of pathology; other patterns, much less so. In some instances an abnormal isotope lymphogram would be a reasonable alternative to the conventional lymphangiogram for staging purposes.

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