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HYDROXYUREA AND RADIATION THERAPY IN ADVANCED NEOPLASMS OF THE HEAD AND NECK

C. JULES ROMINGER M.D.

Twenty-six cases of advanced carcinoma of the head and neck were treated with hydroxyurea. In 21 cases hydroxyurea and radiation therapy were combined. All cases were in Stages III and IV.

While hydroxyurea did enhance the palliative effect of irradiation in recurrent cases, the best results were obtained in 10 previously untreated cases.

In no case was the tumor permanently controlled by the combined course of therapy but the local and regional responses to treatment were greater than anticipated from radiation therapy alone and in most instances the tumor completely disappeared temporarily.

All of the patients, except 2 currently under therapy, unfortunately have expired as a result of their disease.


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