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ADJUVANT CHEMOTHERAPY IN THE RADICAL TREATMENT OF CARCINOMA OF THE BREAST—A CLINICAL TRIAL

R. FINNEY M.B., F.R.C.S. (E), F.F.R.

A report is presented of a randomized clinical trial to investigate the effects of adding a chemotherapeutic agent, i.e., cyclophosphamide, to the routine modalities of surgery and radiation therapy in the radical treatment of operable carcinomata of the breast.

The rationale, protocol and method are outlined and the results shown. Assessment of both immediate as well as longer term effects on malignancy is made.

No undue side effects are noted but the malignancy control in the group given chemotherapy at a minimum of 3 years postoperatively is appreciably worse than in the group not given this agent.


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