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THE MANAGEMENT OF METASTASES TO THE BRAIN BY IRRADIATION AND CORTICOSTEROIDS

JOHN HORTON M.B., CH.B., DONALD H. BAXTER M.D., KENNETH B. OLSON M.D., and THE EASTERN COOPERATIVE ONCOLOGY GROUP

1. The combination of irradiation of the brain and oral prednisone offers only slightly better results in terms of duration of remission and survival than oral prednisone alone in the management of metastatic cancer of the brain.

2. In patients treated with the combination who enter remission, there is probably no advantage to continuing prednisone prophylactically.

3. On subsequent relapse, re-use of prednisone can sometimes be effective.


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