LYMPHOSARCOMA

TREATMENT AND END RESULTS IN 355 PATIENTS

Appropriate study and proper staging of every patient with lymphosarcoma are mandatory in the management of this disease.

Radiation therapy is the principal and preferred form of treatment for most patients with lymphosarcoma.

Patients with unicentric lymphosarcoma should receive 4,000 to 4,500 rads of radiation to the involved site with 3,000 to 3,500 rads to adjacent lymph node-bearing regions.

In a few selected patients, surgical extirpation may be useful. A tumor dose of irradiation should be given these patients following wound healing. Patients with regional lymphosarcoma should be treated with at least 3,500 rads to the diseased sites and 3,000 rads to the adjacent lymph node-bearing regions.

Patients with generalized nodal lymphosarcoma should be given total nodal irradiation whenever feasible, employing, if possible, 3,000 to 3,500 rads. In those in poor clinical condition, when radiation therapy is not feasible, chemotherapy should be employed.

Patients with Stage IV lymphosarcoma, who cannot be given irradiation, should receive chemotherapy to control their disease as long as possible.

Patients with primary extranodal lymphosarcoma should have surgical excision of their tumor and dissection of the adjacent lymph node-bearing regions whenever possible. This should be followed by a full tumor dose of irradiation to the tumor bed.

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