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COMPARATIVE ANALYSIS OF TWO REGIMENS OF SPLIT COURSE RADIATION IN CARCINOMA OF THE LUNG

ROBERT T. GUTHRIE M.D.1, JOHN J. PTACEK M.D.2, and A. CURTIS HASS M.D.3

1 Assistant Professor, Department of Radiology, University of Iowa, Iowa City, Iowa.
2 Resident, Department of Radiology, University of Iowa.
3 Margaret and Howard Hall Radiation Center, Cedar Rapids, Iowa.

Ninety-seven patients were entered into a prospective randomized study of 2 split course regimens of radiation therapy for inoperable carcinoma of the lung.

Group A received a 3,000 rads course with a month’s interval followed by a like course; Group B received an initial course of 2,000 rads in 5 treatments followed by a month’s rest and repetition of the same course.

The survival of the patients completing both segments of the split course was significantly better in Group A than in Group B at 12 months, but not at 18 months. The over-all survival, free of disease, at 24 months was 1 per cent.

Further studies are needed to achieve a better definition of the time/dose relationships in split course therapy for carcinoma of the lung.


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