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DAUNOMYCIN CARDIAC TOXICITY

MICHAEL M. RASKIN M.D.1, M. G. RAJURKAR M.B.B.S.2, and DONALD H. ALTMAN M.D.3

1 Clinical Fellow, American Cancer Society, 1971-1972; Senior Resident in Diagnostic Radiology, Mount Sinai Medical Center, Miami School of Medicine, Miami, Florida.
2 Director of Oncology, Variety Children's Hospital, Miami, Florida.
3 Director of Radiology, Variety Children's Hospital; Clinical Professor of Radiology and Pediatrics, University of Miami School of Medicine, Miami, Florida.

The cardiac toxicity of daunomycin is probably related to the cumulative dose rather than to the length of time of treatment or the time interval since discontinuing therapy. This effect occurs more frequently and at lower doses than originally thought.

A persistently increased cardiothoracic ratio may be a suggestive roentgenographic sign of a delayed manifestation of cardiac toxicity in patients receiving re-inducer courses of daunomycin for acute lymphocytic leukemia.

This diagnosis should be considered in children receiving daunomycin who develop signs of cardiac failure after cessation of the drug.


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