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RADIATION DOSE TO VARIOUS ORGAN SITES IN A TISSUE-EQUIVALENT HUMAN PHANTOM RESULTING FROM IMPLANTATION OF A PROMETHIUM 147 (Pm147) INTRACARDIAC NUCLEAR PACEMAKER

W. ARNOLD , J. G. KEREIAKES , G. BAHR , E. L. SAENGER , and J. W. SPICKLER 1

1 Cox Heart Institute, Dayton, Ohio.

A prototype self-contained intracardiac (IC) pacemaker, using promethium 147 (Pm147), has been developed.

The IC pacemaker is designed to be implanted transvenously, via the right jugular vein, into the right ventricle and anchored by means of 2 semicircular barbs.

One important aspect, before the IC pacemaker is used clinically, is the potential radiation hazard involved when a device of this type is implanted in a human being. Radiation doses to heart muscle and to other organs and tissues were measured using thermoluminescence dosimetry and a tissue-equivalent human phantom.

On the basis of present evidence, it seems quite unlikely that the doses (1,350 rads and 883 rads, over a 5 year implantation period, to small volumes of endocardium and myocardium, respectively) delivered at very low dose rates would produce any clinically significant lesion.


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