EFFECT OF REACTIVE HYPEREMIA ON THE DISTRIBUTION OF RADIOACTIVE MICROSPHERES IN PATIENTS WITH PERIPHERAL VASCULAR DISEASE

Using intraarterial injections of Tc^99m and In^113m labeled albumin microspheres we are able to generate, employing a rectilinear scanner, comparative peripheral perfusion scans at rest and with the vasculature under stress.

We have chosen what appears to be the most reliable means of producing significant vasodilatation, that being reactive hyperemia, as the stress. The perfusion scans obtained, when compared, demonstrate the dynamic changes which occur in peripheral perfusion when stressed. Although, at this time, our clinical experience is limited, we are encouraged by our initial findings and believe that the procedure may prove to be both diagnostically and prognostically significant in the evaluation of peripheral vascular disease.

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