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COMPARISON OF THE OPACIFYING CHARACTERISTICS AND PHARMACOLOGIC RESPONSES OF IOCETAMIC ACID (CHOLEBRINE), A NEW ORAL CHOLECYSTOGRAPHIC AGENT, WITH SODIUM TYROPANOATE (BILOPAQUE)

DAVID L. WISHART M.D.1 and CHARLES T. DOTTER M.D.

1 1020 W. Fifth, Olympia, Washington 98501.

A double-blind comparative study of Cholebrine, 4.5 gm., and Bilopaque, 3.0 gm., was conducted in 51 patients to determine the incidence, type, and severity of side effects, gallbladder opacifying characteristics, and pharmacologic effects as evaluated by a series of laboratory tests of hematologic, renal, thyroid and liver functions.

The observed changes in laboratory values were small, tended to occur with both drugs, were questionably related to drug administration and of dubious clinical significance.

Cholebrine and Bilopaque are comparable with respect to the properties forming the basis of this comparative study.


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