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GANGLIOSIDOSIS (GM1)

A RE-EVALUATION OF THE VERTEBRAL DEFORMITY

JACK G. RABINOWITZ M.D.1 and MICHAEL SACHER M.D.

1 University of Tennessee Medical Units, Memphis, Tennessee.

Vertebral bodies in a patient with gangliosidosis (GM1) demonstrating the characteristic notch deformity were examined pathologically.

Only hyaline cartilage accumulation was noted in the area of the deformity. This finding suggested that the abnormality is due to asymmetric growth, caused by excessive stress directed anteriorly upon the vertebral bodies of L1 and L2.


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