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NEONATAL TRANSPLACENTAL RUBELLA SYNDROME

ITS EFFECT ON NORMAL MATURATION OF THE DIAPHYSIS

JOSEPH P. WHALEN M. D., PATRICIA WINCHESTER M.D., LENNART KROOK D.V.M., PH.D., NEIL O’DONOHUE M.D., RENATE DISCHE M.D., and ELADIO NUNEZ PH.D.

Modeling of the femur diaphysis in the perinatal period was studied in 30 normal fetuses and infants and in 5 cases of transplacental rubella.

The total diameter and medullary cavity width increase progressively with increasing body weight. In subperiosteal trabeculae there is a high apposition to resorption ratio and bone mass increases. In trabeculae facing the medullary cavity there is a high resorption to apposition ratio; bone mass decreases and the medullary cavity expands. Bone resorption is by osteocytic osteolysis.

In transplacental rubella, the diaphyseal modeling is delayed beyond the limits of physiologic sclerosis. Normal modeling is achieved within 2 months, coincident with correction of the metaphyseal abnormalities.


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